Environmental toxicants, oxidative stress and health adversities: interventions of phytochemicals
| Autor: | Anurag Sharma, Smitha Hegde, Jagdish Gopal Paithankar, Shiwangi Dwivedi, Sharanya Kushalan, Leonard Clinton D'Souza |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Pharmacology
0303 health sciences business.industry Phytochemicals Pharmaceutical Science Antioxidant response element Bioinformatics medicine.disease_cause Antioxidants Oxidative Stress 03 medical and health sciences 0302 clinical medicine Environmental toxicology Medicine business Oxidation-Reduction 030217 neurology & neurosurgery Oxidative stress 030304 developmental biology |
| Zdroj: | Journal of Pharmacy and Pharmacology. 74:516-536 |
| ISSN: | 2042-7158 0022-3573 |
| Popis: | Objectives Oxidative stress is the most common factor mediating environmental chemical-induced health adversities. Recently, an exponential rise in the use of phytochemicals as an alternative therapeutics against oxidative stress-mediated diseases has been documented. Due to their free radical quenching property, plant-derived natural products have gained substantial attention as a therapeutic agent in environmental toxicology. The present review aimed to describe the therapeutic role of phytochemicals in mitigating environmental toxicant-mediated sub-cellular and organ toxicities via controlling cellular antioxidant response. Methods The present review has covered the recently related studies, mainly focussing on the free radical scavenging role of phytochemicals in environmental toxicology. Key findings In vitro and in vivo studies have reported that supplementation of antioxidant-rich compounds can ameliorate the toxicant-induced oxidative stress, thereby improving the health conditions. Improving the cellular antioxidant pool has been considered as a mode of action of phytochemicals. However, the other cellular targets of phytochemicals remain uncertain. Conclusions Knowing the therapeutic value of phytochemicals to mitigate the chemical-induced toxicity is an initial stage; mechanistic understanding needs to decipher for development as therapeutics. Moreover, examining the efficacy of phytochemicals against mixer toxicity and identifying the bioactive molecule are major challenges in the field. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|