Apolipoprotein B Gene Polymorphisms and Dyslipidemia in HIV Infected Adult Zimbabweans
Autor: | Danai Tavonga Zhou, Babill Stray-Pedersen, Kerina Duri, Exnevia Gomo, Olav Oektedalen, Vitaris Kodogo |
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Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Apolipoprotein B Lipoproteins Article EcoR1 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine High-density lipoprotein Virology Genotype medicine 030212 general & internal medicine Allele Genotyping biology business.industry Public Health Environmental and Occupational Health Wild type HIV medicine.disease 030112 virology CHD Infectious Diseases Dyslipidemia chemistry Immunology biology.protein Xba1 APOB business ART Lipoprotein |
Zdroj: | The Open AIDS Journal |
ISSN: | 1874-6136 |
Popis: | Background:Dyslipidemia does not occur in all HIV-infected or antiretroviral therapy-experienced patients suggesting role of host genetic factors but there is paucity of data on association between dyslipidemia and gene polymorphisms in Zimbabwe.Objective:To determine association of lipoprotein levels andapolipoprotein Bpolymorphisms in HIV-infected adults.Method:Demographic data were collected from 103 consenting patients; lipoprotein levels were determined and blood samples were successfully genotyped for bothapolipoprotein B2488C>T Xba1 andapolipoprotein B4154G>A p.Gln4154Lys EcoR1 polymorphisms by real time polymerase chain reaction.Results:Mean age of genotyped patients was 40.3 ± 10.1 years, 68% were female; prevalence of dyslipidemia was 67.4%. Of 103 samples genotyped forapolipoprotein BXba1 polymorphism, 76 (74%) were homozygous C/C, 24 (23%) were heterozygous C/T and only three (3%) were homozygous T/T.Apolipoprotein BEcoR1 polymorphism showed little variability, one participant had rare genotype A/A, 68.3% had wild type genotype G/G.Conclusion:Observed frequencies ofapolipoprotein BXbaI and EcoRI polymorphisms matched other African studies. In spite of low numbers of rare variants, there was positive association between both total cholestrol and high density lipoprotein with ECoR1 wild type G/G genotype, suggesting that ECoRI 4154 G allele could be more protective against coronary heart disease than EcoR1 4154 A allele. There is need for further research at population level to confirm whetherapolipoprotein BECoR1 genotyping is useful for predicting risk of dyslipidemia in HIV patients in our setting. |
Databáze: | OpenAIRE |
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