The benefits of integration
| Autor: | A. Ciuffi |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) viruses Virus Integration Endogenous retrovirus integration Viral transformation Virus lens-epithelium derived growth factor/p75 03 medical and health sciences Retrovirus Humans human immunodeficiency virus 030102 biochemistry & molecular biology biology nuclear pore proteins persistence General Medicine Provirus biology.organism_classification nuclear import Virology Reverse transcriptase 3. Good health retrovirus 030104 developmental biology Infectious Diseases Retroviridae Viral replication Host-Pathogen Interactions integrase |
| Zdroj: | Clinical Microbiology and Infection |
| ISSN: | 1469-0691 |
| Popis: | Retroviruses, including the human immunodeficiency virus (HIV), are notorious for two essential steps of their viral replication: reverse transcription and integration. This latter property is considered to be essential for productive replication and ensures the stable long-term insertion of the viral genome sequence in the host chromatin, thereby leading to the life-long association of the virus with the infected cell. Using HIV as a prototypic example, the present review aims to provide an overview of how and where integration occurs, as well as presenting general consequences for both the virus and the infected host. |
| Databáze: | OpenAIRE |
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