Metabolic targeting of Carbonic Anhydrase 2 (CA-2) overcomes temozolomide resistance in GBM stem cells

Autor: Zhao, K, Culmsee, C, Nimsky, C, Bartsch, JW
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCP154 /20220525/
DOI: 10.3205/22dgnc467
Popis: Objective: About 95 % of GBM patients show tumor relapse leaving them with limited therapeutic options as recurrent tumors are often resistant to temozolomide (TMZ). GBM-like stem cells (GSCs) are considered as the major obstacle in therapy resistance, so the characterization of their response [for full text, please go to the a.m. URL]
Databáze: OpenAIRE