Water-Dispersible Silica-Coated Upconverting Liposomes: Can a Thin Silica Layer Protect TTA-UC against Oxygen Quenching?
| Autor: | Sven H. C. Askes, Hadi Arjmandi-Tash, Thomas Schmidt, Vincent Christiaan Leeuwenburgh, Wim Pomp, Sylvestre Bonnet, Stefania Tanase |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
liposomes
Materials science Biomedical Engineering Nanoparticle chemistry.chemical_element 02 engineering and technology engineering.material 010402 general chemistry Photochemistry 01 natural sciences Oxygen Article Biomaterials Coating silica coating Liposome Nanocomposite Quenching (fluorescence) oxygen quenching light upconversion respiratory system 021001 nanoscience & nanotechnology photonic materials Photon upconversion 0104 chemical sciences chemistry engineering nanoparticles 0210 nano-technology Layer (electronics) |
| Zdroj: | ACS Biomaterials Science & Engineering ACS Biomaterials Science and Engineering, 3(3), 322-334 ACS Biomaterials Science and Engineering |
| Popis: | Light upconversion by triplet-triplet annihilation (TTA-UC) in nanoparticles has received considerable attention for bioimaging and light activation of prodrugs. However, the mechanism of TTA-UC is inherently sensitive for quenching by molecular oxygen. A potential oxygen protection strategy is the coating of TTA-UC nanoparticles with a layer of oxygen-impermeable material. In this work, we explore if (organo)silica can fulfill this protecting role. Three synthesis routes are described for preparing water-dispersible (organo)silica-coated red-to-blue upconverting liposomes. Their upconversion properties are investigated in solution and in A549 lung carcinoma cells. Although it was found that the silica offered no protection from oxygen in solution and after uptake in A549 cancer cells, upon drying of the silica-coated liposome dispersion in an excess of (organo)silica precursor, interesting liposome-silica nanocomposite materials were obtained that were capable of generating blue light upon red light excitation in air. |
| Databáze: | OpenAIRE |
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