Early and Late Radiation Changes Following a Second Course of Irradiation

Autor:	Brown Jm, Probert Jc
Rok vydání:	1975
Předmět:	medicine.medical_specialty End point business.industry Dose-Response Relationship Radiation Radiotherapy Dosage Hindlimb Surgery Mice Skin reaction Fractionated irradiation Deformity Animals Medicine Radiology Nuclear Medicine and imaging Irradiation medicine.symptom business Skin
Zdroj:	Radiology. 115:711-716
ISSN:	1527-1315 0033-8419
DOI:	10.1148/15.3.711
Popis:	The effect of two 10-fraction courses of irradiation separated by intervals varying from 1 to 10 months on both the early skin reaction and late deformity of the leg was studied in mice. It was found that the "memory" of the first course was much greater for the late end point (deformity) than for early skin reactions at all intervals between the two courses. The extent of the late deformity reaction following a second course was predicted fairly well from the Ellis formula for decay of partial tolerance, but it also appeared to be more complex than is evident from the formula. Evaluation of early vs. late reactions showed that the extent of the deformity is not governed entirely by the level of the early skin reaction; rather, it depends critically on the previous radiation history of the tissue.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620e74faf5f25b994e3885dace6a43a2 https://doi.org/10.1148/15.3.711 Zobrazit plný text záznamu