Diacerein attenuates vascular dysfunction by reducing inflammatory response and insulin resistance in type 2 diabetic rats
| Autor: | Jian Shen, Minghao Luo, Yuanjing Li, Longxiang Huang, Xiang Li, Yuzhou Xue, An He, Dingyi Lv |
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| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
Male Anti-Inflammatory Agents Biophysics Anthraquinones Aorta Thoracic Inflammation Type 2 diabetes Pharmacology Biochemistry Diabetes Mellitus Experimental Rats Sprague-Dawley Insulin resistance Diabetes mellitus medicine Animals Diacerein Molecular Biology Molecular Structure biology business.industry Insulin tolerance test NF-kappa B Cell Biology medicine.disease Streptozotocin Insulin receptor Diabetes Mellitus Type 2 biology.protein Cytokines Insulin Resistance Nitric Oxide Synthase medicine.symptom business Signal Transduction medicine.drug |
| Zdroj: | Biochemical and Biophysical Research Communications. 585:68-74 |
| ISSN: | 0006-291X |
| Popis: | Aim To examine the effect of diacerein on vascular dysfunction in type 2 diabetic rats and elucidate the mechanism of diacerein. Methods In a rat model, type 2 diabetes was induced by high-fat diet and streptozotocin. Vascular function was assessed in vascular reactivity experiment. The effect of diacerein (10 or 20 mg/kg/day) on blood glucose, inflammation and insulin signaling, and modulators in vascular tissue in diabetic rats were investigated by molecular and biochemical approaches. Results In this study, diacerein inhibited diabetes-induced vascular dysfunction. Diacerein treatment normalized blood glucose, insulin tolerance test, inflammatory cytokine levels and nitric oxide synthases expression in diabetic rats. Moreover, diacerein inhibited NF-κB and NLRP3 pathways and activated insulin signaling pathway related proteins IRS-1 and AKT in diabetic rats. Conclusion Diacerein improved vascular function effectively in diabetic rats by suppressing inflammation and reducing insulin resistance. These results suggest that diacerein may represent a novel therapy for patients with diabetes. |
| Databáze: | OpenAIRE |
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