Unexpectedly high levels of some presumably protective secretory immunoglobulin A antibodies to dental plaque bacteria in salivas of both caries-resistant and caries-susceptible subjects
| Autor: | Jean-Pierre Bouvet, H. Hocini, Jacques Pillot, S Iscaki |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Saliva Immunology Dental Plaque Dental Caries medicine.disease_cause Dental plaque Microbiology Streptococcus sobrinus Antigen Western blot medicine Humans biology medicine.diagnostic_test Streptococcus Middle Aged biology.organism_classification medicine.disease Antibodies Bacterial Immunity Innate Infectious Diseases Immunoglobulin A Secretory Humoral immunity biology.protein Female Parasitology Disease Susceptibility Antibody Research Article |
| Zdroj: | Infection and Immunity. 61:3597-3604 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.61.9.3597-3604.1993 |
| Popis: | The role of salivary antibodies in protection against cariogenic bacteria is actually a matter of debate. Correlation between caries experience and naturally occurring antibodies was extensively investigated. Comparison of salivary antibodies from 21 caries-resistant and 22 caries-susceptible subjects was carried out by using a new quantitative method. Secretory immunoglobulin A (S-IgA) antibodies to Streptococcus sobrinus and Streptococcus sanguis cells were detected in all salivas and at similar levels in both groups. When assayed with two major antigens from S. sobrinus, i.e., protein antigen I/II and cell wall carbohydrates, only specific activities of antibodies to the protein component were increased (P < 0.01), but this occurred unexpectedly in the caries-susceptible group. Western blot (immunoblot) analysis with the culture supernatant and cell wall proteins from S. sobrinus showed the same antibody specificity in both groups. No selective increase of the protease-resistant S-IgA2 subclass was found, and avidities of antibodies to both antigen I/II and cell wall carbohydrates were similar. Our results demonstrate that naturally induced S-IgA antibodies against S. sanguis, S. sobrinus, and the major antigens of the latter are not sufficient to inhibit caries development. |
| Databáze: | OpenAIRE |
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