Soluble intercellular adhesion molecule-1 (sICAM-1) as a marker of disease relapse in idiopathic uveoretinitis
| Autor: | Miles Stanford, Dudley C. Dumonde, H. Direskeneli, Graham R. Wallace, G. R. V. Hughes, C. Edelsten, B. A. Ellis, A. G. Zaman, Elizabeth M. Graham, David D'Cruz |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Systemic disease Adolescent Endothelium Immunology Uveitis Pathogenesis Von Willebrand factor Recurrence von Willebrand Factor medicine Humans Immunology and Allergy Endothelial dysfunction Aged biology Cell adhesion molecule business.industry Retinitis Middle Aged Intercellular Adhesion Molecule-1 medicine.disease C-Reactive Protein medicine.anatomical_structure biology.protein Female E-Selectin business Cell Adhesion Molecules Biomarkers Research Article Retinopathy |
| Zdroj: | Clinical and Experimental Immunology. 95:60-65 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.1994.tb06015.x |
| Popis: | SUMMARYThis study reports the results of a point prevalence study of markers of endothelial dysfunction in the serum of patients with idiopathic uveoretinitis. sICAM-l, soluble endothelial leucocyte adhesion molecule (sELAM), anti-endothelial cell antibodies (AECA) and von Willebrand factor (vWF) levels were measured in 32 patients with isolated idiopathic uveoretinitis and seven with uveitis in association with systemic disease, using commercial and in-house ELISAs. Raised levels of AECA were found in 31% of patients with isolated uveitis, vWFin 28%, sELAM in 15.6% and sICAM-1 in 31%. Further analysis revealed that raised sICAM-1 levels were closely associated with recent relapse of disease (P=0.00003). Patients with accompanying systemic disease were found to have a similar prevalence of these serum abnormalities to those with isolated ocular disease. In conclusion, vascular endothelial dysfunction may contribute to pathogenesis in uveoretinitis, and in particular sICAM-1 may prove a marker of disease relapse in this condition. |
| Databáze: | OpenAIRE |
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