Cytokine Combination Therapy with Erythropoietin and Granulocyte Colony Stimulating Factor in a Porcine Model of Acute Myocardial Infarction
| Autor: | Lauren Bartlett, Franca S. Angeli, Yerem Yeghiazarians, Andrew J. Boyle, Rachel Mirsky, Mia Shapiro, Yan Zhang, Renu Virmani, William Grossman, Kanu Chatterjee, Nicolas Amabile |
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| Rok vydání: | 2010 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Combination therapy Swine Heart Ventricles Myocardial Infarction Bone Marrow Cells Article Pharmacotherapy Drug Therapy Internal medicine Granulocyte Colony-Stimulating Factor medicine Animals Pharmacology (medical) Myocardial infarction Erythropoietin Cytokine Cardiac remodeling Pharmacology Ejection fraction Animal business.industry Myocardium Heart Stroke Volume Pharmacology and Pharmaceutical Sciences General Medicine Stroke volume medicine.disease Granulocyte colony-stimulating factor Cardiovascular System & Hematology Echocardiography Granulocyte colony stimulating factor Disease Models Combination Cardiology Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Cardiovascular Drugs and Therapy Cardiovascular drugs and therapy, vol 24, iss 5-6 |
| ISSN: | 1573-7241 0920-3206 |
| DOI: | 10.1007/s10557-010-6263-7 |
| Popis: | Purpose Erythropoietin (EPO) and granulocyte colony stimulating factor (GCSF) have generated interest as novel therapies after myocardial infarction (MI), but the effect of combination therapy has not been studied in the large animal model. We investigated the impact of prolonged combination therapy with EPO and GCSF on cardiac function, infarct size, and vascular density after MI in a porcine model. Methods MI was induced in pigs by a 90 min balloon occlusion of the left anterior descending coronary artery. 16 animals were treated with EPO+GCSF, or saline (control group). Cardiac function was assessed by echocardiography and pressure-volume measurements at baseline, 1 and 6 weeks post-MI. Histopathology was performed 6 weeks post-MI. Results At week 6, EPO+GCSF therapy stabilized left ventricular ejection fraction, (41 ± 1% vs. 33 ± 1%, p |
| Databáze: | OpenAIRE |
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