Genome-wide Association Study Signal at the 12q12 Locus for Crohn’s Disease May Represent Associations with the MUC19 Gene
| Autor: | Devendra Amre, David R. Mack, Philippe Lambrette, David M. Israel, Valérie Marcil, Irina Costea, Jinsong Dong, Alfreda Krupoves, Guy Grimard, Emile Levy, Ernest G. Seidman, Vijay Kumar |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Adolescent Genotype Genome-wide association study Locus (genetics) Single-nucleotide polymorphism Protein Serine-Threonine Kinases Biology Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Polymerase Chain Reaction Polymorphism Single Nucleotide Crohn Disease Risk Factors Humans Immunology and Allergy SNP Genetic Predisposition to Disease Allele Child Alleles Genetic association Genetics Chromosomes Human Pair 12 Haplotype Mucins Gastroenterology Prognosis Haplotypes Case-Control Studies Female Genome-Wide Association Study |
| Zdroj: | Inflammatory Bowel Diseases. 19:1254-1259 |
| ISSN: | 1078-0998 |
| DOI: | 10.1097/mib.0b013e318281f454 |
| Popis: | Background: Genome-wide association studies (GWAS) in Crohn's disease (CD) have identified associations with single-nucleotide polymorphism (SNP) rs11175593 at chromosome 12q12. The MUC19 and LRRK2 genes reside close to the GWAS signal, but it is as yet unclear which of the 2 genes represent the CD susceptibility genes. Methods: We studied associations between nonsynonymous coding variants in the MUC19 (5) and LRRK2 (3) genes in a case-control sample comprising CD cases aged |
| Databáze: | OpenAIRE |
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