| Autor: |
Hisami Rodriguez-Matsui, David M. Aparicio, María L. Orea, Jorge R. Juárez, Victor Gómez-Calvario, Dino Gnecco, Alan Carrasco-Carballo, And Joel L. Terán |
| Rok vydání: |
2023 |
| Předmět: |
|
| DOI: |
10.20944/preprints202304.0188.v1 |
| Popis: |
The first diastereoselective synthesis of (–)-1-epi-lentiginosine stars from a common chiral trans-epoxyamide derived from 2-pyridincarbaldehyde is reported. This methodology involves a sequential oxirane ring opening and intramolecular 5-exo-tet cyclization of tosylate tras-epoxyalcohol to afford a diastereomeric mixture of indolizinium salts in a one-pot fashion, followed by regio- and diastereospecific pyridinium ring reduction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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