RELEASE OF A SUBSTANCE FROM THE HUMAN PLACENTA HAVING DIGOXIN-LIKE IMMUNOREACTIVITY
| Autor: | M.A. Read, A. Di Grande, L. S. Malatino, A.L.A. Boura, William A. W. Walters |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
Digoxin medicine.medical_specialty Adolescent Physiology Placenta Prostaglandin Vasodilation Dinoprost Ouabain Veins chemistry.chemical_compound Physiology (medical) Internal medicine Fluorescence Polarization Immunoassay Humans Medicine Pharmacology Fetus business.industry Blood Proteins Saponins Fetal Blood Perfusion Cardenolides medicine.anatomical_structure Fetal circulation Endocrinology chemistry Vasoconstriction embryonic structures Female medicine.symptom business medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 20:603-607 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.1993.tb01747.x |
| Popis: | SUMMARY 1. The human placental lobule, perfused with a constant flow (5 mL/min) of Krebs’ solution after delivery at term, released into the fetal perfusate a digoxin-like substance, as measured by a fluorescence polarization immunoassay. 2. Initially the venous concentration was 360 ± 66.7 pmol/ L digoxin equivalents. This level did not change significantly during fetal vasoconstriction induced by prostaglandin F2α infusion and persisted for the duration of the experiment (1.5–2h). 3. Infusion into the fetal circulation of Fab fragments of sheep antibodies to digoxin caused vasodilatation, indicated by a fall in perfusion pressure. 4. Thus a digoxin-like immunoreactive substance, previously reported to be present in the placenta, is released into the fetal circulation and may play a role in placental control of fetal vascular tone. |
| Databáze: | OpenAIRE |
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