Well-Defined Bifunctional Dendrimer Bearing 54 Nitric Oxide-Releasing Moieties and 54 Ursodeoxycholic Acid Groups Presenting High Anti-Inflammatory Activity

Autor: Ana M. Garzón-Porras, Diego L. Bertuzzi, Kurt Lucas, Catia Ornelas
Rok vydání: 2022
Předmět:
Zdroj: ACS Biomaterials Science & Engineering. 8:5171-5187
ISSN: 2373-9878
DOI: 10.1021/acsbiomaterials.2c00713
Popis: Nitric oxide (NO) and ursodeoxycholic acid (UDCA) are endogenous molecules involved in physiological processes associated with inflammation. Since inflammatory processes are present in the mechanisms of many diseases, these molecules are important for the development of new drugs. Herein, we describe the synthesis of a well-defined bifunctional dendrimer with 108 termini bearing 54 NO-releasing groups and 54 UDCA units (Dendri-(NO/UDCA)
Databáze: OpenAIRE