Calea zacatechichi Schltdl. (Compositae) produces anxiolytic- and antidepressant-like effects, and increases the hippocampal activity during REM sleep in rodents
| Autor: | Adrián Cruz-Tavera, Lilian Mayagoitia-Novales, Ignacio Ramírez-Salado, Julia Cassani, Rosa Estrada-Reyes, Manuel Alejandro Cruz-Aguilar, Lucía Martinez-Mota, Ana María Dorantes-Barrón, Daniel Arrieta-Baez |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.drug_class Hippocampus Sleep REM Pharmacology Electroencephalography Hippocampal formation Asteraceae Anxiolytic Antidepressant like 03 medical and health sciences Mice 0302 clinical medicine Cognition Drug Discovery Medicine Animals Rats Wistar Mexico 030304 developmental biology Slow-wave sleep 0303 health sciences Sleep Stages medicine.diagnostic_test Behavior Animal Dose-Response Relationship Drug business.industry Plant Extracts Sleep in non-human animals Antidepressive Agents Rats Anti-Anxiety Agents 030220 oncology & carcinogenesis business Sleep |
| Zdroj: | Journal of ethnopharmacology. 265 |
| ISSN: | 1872-7573 |
| Popis: | Ethnopharmacological relevance Calea zacatechichi is a plant with an extensive popular and ritual use in Mexico. In healthy volunteers, it induces well-being and tranquility senses, and facilitates superficial stages of sleep. However, anxiolytic, and antidepressant-like effects and changes on the sleep-waking stages have not been explored. Aim To determine anxiolytic and antidepressant-like effects of an aqueous extract of C. zacatechichi (CZ) in rodents and to analyze their effects on hippocampal activity in the rat sleep-waking cycle. Material and methods CZ anxiolytic- and antidepressant-like effects were evaluated in several mice and rat behavioral paradigms. CZ effects on temporal distribution of sleep were described, and hippocampus EEG frequency patterns were analyzed during the sleep-waking cycle; absolute and relative powers were analyzed during Rapid Eye Movements (REM) and non-REM sleep stages. CZ chemical analysis was performed by UPLC-ESI-MS. Results CZ produced specific and robust anxiolytic- and antidepressant-like effects in mice and rats, similar to those of prototypical drugs, at doses ranging from 0.5 to 50 mg/kg. CZ at 100 mg/kg produced visible mild sedative effects in rats, associated with a significant increase in Slow Wave Sleep episodes during a 6 h recording, and enhanced fast frequencies of hippocampus (gamma-band:31–50 Hz) during REM sleep. Conclusion Results could support the well-being and tranquility senses reported by healthy consumers, and to explain the oneiric content during dreams and some improvements in cognitive processes described by consumers. Anxiolytic- and antidepressant-like effects of this species, reported for first time in this study could improve some aspects of mental health. |
| Databáze: | OpenAIRE |
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