Effect of plastoquinone derivative 10-(6′-Plastoquinonyl) decyltriphenylphosphonium (SkQ1) on estrous cycle and 17β-estradiol level in rats
| Autor: | S. V. Dem’yanenko, A. A. Alexandrova, O. N. Kosheleva, L. V. Gutnikova, V. N. Prokof'ev, Vladimir A. Chistyakov |
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| Rok vydání: | 2012 |
| Předmět: |
Estrous cycle
endocrine system medicine.medical_specialty Dose-Response Relationship Drug Estradiol Plastoquinone urogenital system Chemistry 10-(6'-plastoquinonyl)decyltriphenylphosphonium Estrous Cycle General Medicine Derivative Biochemistry Rats chemistry.chemical_compound Endocrinology Internal medicine medicine Animals Female Rats Wistar reproductive and urinary physiology hormones hormone substitutes and hormone antagonists |
| Zdroj: | Biochemistry (Moscow). 77:1382-1386 |
| ISSN: | 1608-3040 0006-2979 |
| DOI: | 10.1134/s0006297912120061 |
| Popis: | Administration of the plastoquinone derivative 10-(6'-plastoquinonyl)decyltriphenylphosphonium (SkQ1) to female Wistar rats with regular estrous cycle once a day for two weeks at doses of 25 nmol/kg (but not 250 nmol/kg) leads to increase in proestrus duration by reducing the phase of diestrus and metestrus. Neither dose caused significant changes in serum 17β-estradiol level for any stage of the cycle. However, relative elongation of the proestrus stage leads to an increase in average per cycle estradiol levels by 20%. |
| Databáze: | OpenAIRE |
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