Correlation between therapy response assessment using FDG PET/CT and histopathologic tumor regression grade in hepatic metastasis of colorectal carcinoma after neoadjuvant therapy
| Autor: | Irene A. Burger, Esther I. Schwarz, Achim Weber, Stefan Breitenstein, Andrei Samarin, Thomas F. Hany |
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| Přispěvatelé: | University of Zurich, Burger, Irene A |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Colorectal cancer medicine.medical_treatment Standardized uptake value 610 Medicine & health Multimodal Imaging Correlation Fluorodeoxyglucose F18 10049 Institute of Pathology and Molecular Pathology medicine Humans 2741 Radiology Nuclear Medicine and Imaging Radiology Nuclear Medicine and imaging Neoadjuvant therapy 10217 Clinic for Visceral and Transplantation Surgery Tumor Regression Grade Chemotherapy Receiver operating characteristic business.industry Liver Neoplasms Biological Transport General Medicine 10181 Clinic for Nuclear Medicine Middle Aged medicine.disease Neoadjuvant Therapy Confidence interval Treatment Outcome ROC Curve Positron-Emission Tomography Female Radiology Neoplasm Grading Colorectal Neoplasms Tomography X-Ray Computed business |
| Popis: | To evaluate the correlation between change in FDG uptake before and after chemotherapy in hepatic metastases of colorectal carcinoma (HCRC) and a histopathologic tumor regression grade (TRG). In patients with HCRC, PET/CT data prior to hepatic surgery were retrospectively analyzed under an IRB waiver. The maximum standard uptake value (SUVmax) was measured before and after chemotherapy. The relative change of FDG activity in the identified lesions was calculated (dSUV). Histopathological specimens of resected metastases were graded on a 5-score TRG scale. A TRG of 1–3 was rated as a responding to therapy, whereas TRG 4–5 were regarded as non-responding lesions. 31 lesions were identified in 23 patients. Mean SUVmax before and after therapy was 6.9 ± 3.7 and 3.5 ± 1.8, respectively. The area under the receiver operator characteristic curve revealed a conclusive correlation between TRG and dSUV (AUC 0.773; 95 % confidence interval 0.599–0.946) with a cut off at 41 % decrease in FDG activity yielding a sensitivity and specificity of 72 and 75 %, respectively. A relative change in FDG activity (dSUV) of more than 41 % decrease correlated significantly with histopathological tumor regression and might be a prognostic tool for response to chemotherapy in HCRC. |
| Databáze: | OpenAIRE |
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