Production of interferon γ in asthmatic patients with small bacille Calmette-Guerin scars: A pilot study
| Autor: | Débora Schor, Silvia Maria Lucena Montenegro, Clarice Neuenschwander, Silvia Wanick Sarinho, Rosangela De M. Queiroz, Francisca Hosana Bezerra de Oliveira, Emanuel Sarinho, Décio Medeiros |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Adolescent Scars Pilot Projects Stimulation Immunoglobulin E Cicatrix Interferon-gamma chemistry.chemical_compound Antibody Specificity medicine Animals Humans Immunology and Allergy Interferon gamma Child Asthma biology business.industry Pyroglyphidae General Medicine Eosinophil medicine.disease medicine.anatomical_structure chemistry Immunology Ionomycin BCG Vaccine biology.protein Female medicine.symptom business BCG vaccine Biomarkers medicine.drug |
| Zdroj: | Allergy and Asthma Proceedings. 27:516-522 |
| ISSN: | 1088-5412 |
| DOI: | 10.2500/aap.2006.27.2907 |
| Popis: | Some studies suggest a decrease in interferon (IFN) gamma production among atopic individuals, and others refer to low IFN-gamma levels as a characteristic of asthma, regardless of the atopic state. Recent research has indicated a relation between asthma and a tendency toward a bacille Calmette-Guerin (BCG) vaccine scar with a small diameter, suggesting an association of this illness with the low production of IFN-gamma. The aim of this study was to check the hypothesis that asthmatic patients with a small BCG scar present low IFN-gamma production. This work was a quasi-experimental study. The capacity to produce IFN-gamma among 12 asthmatic patients with an average BCG vaccine scar diameter5 mm was compared with 7 nonasthmatic individuals with scarsor =5 mm using whole blood cells stimulated by purified protein derivative (PPD), phorbol myristate acetatelionomycin (PMA/Iono) and medium (no stimulus). The study also analyzed the relation between IFN-gamma production after PPD stimulation and eosinophil count, total IgE, and dust-mite-specific IgE levels. The asthmatic patients presented a decrease in IFN-gamma production in comparison with a control group after PPD stimulation (p0.02). However, the same was not observed when PMA/Iono stimulation was used or when no stimulation was used. Asthmatic patients with small BCG scars showed a decrease in IFN-gamma production, suggesting that there may be an intrinsic characteristic of these patients. |
| Databáze: | OpenAIRE |
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