Hypercalcemia With Disseminated Osteolytic Lesions: A Rare Presentation of Adulthood Acute Lymphoblastic Leukemia
| Autor: | May Denewer, Noha Eisa, Adel El-Badrawy, Basma Atef, Shaimaa El-Ashwah, Yasmine Essam, Mohamed Mabed |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty 060101 anthropology 060102 archaeology endocrine system diseases business.industry Lymphoblastic Leukemia Induction chemotherapy nutritional and metabolic diseases Case Report 06 humanities and the arts Acute lymphoblastic leukemia Dermatology Bone lesion Hypercalcemia Medicine Osteolytic bone lesions 0601 history and archaeology Presentation (obstetrics) business Prospective cohort study hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Hematology |
| ISSN: | 1927-1220 1927-1212 |
| Popis: | Osteolytic bone lesions and hypercalcemia without peripheral blasts B-cell acute lymphoblastic leukemia (B-ALL) are reported in children but rarely seen in adults. Herein, we described two patients with B-ALL presenting with hypercalcemia and symptomatic osteolytic bone lesions. They were treated by standard induction chemotherapy after correction of hypercalcemia with supportive measures. With this two case reports we would like to emphasize the importance of clinical awareness of hypercalcemia and osteolytic bone lesions as rare presentations of ALL. The prognostic implication of bone lesions and hypercalcemia in ALL is unclear and needs to be verified in large prospective studies. However, immediate recognition and treatment of hypercalcemia and the underlying B-ALL are vital since a delay of diagnosis poses a possible life-threatening risk. J Hematol. 2018;7(4):154-157 doi: https://doi.org/10.14740/jh455w |
| Databáze: | OpenAIRE |
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