NCAM (neural cell adhesion molecules) expression in malignant mesotheliomas
| Autor: | Christian Brambilla, Marie Helene Laverriere, Elisabeth Brambilla, Gilles Frey, Denis Moro, Nathalie Sturm, Sylvie Lantuejoul |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Mesothelioma Pathology medicine.medical_specialty Lung Neoplasms Synaptophysin Adenocarcinoma Epithelium Pathology and Forensic Medicine Metastasis Immunoenzyme Techniques Carcinoma Non-Small-Cell Lung Biomarkers Tumor Chromogranins Medicine Humans Neural Cell Adhesion Molecules Aged Aged 80 and over biology business.industry Cell adhesion molecule Chromogranin A Epithelial Cells Middle Aged medicine.disease Mesothelium medicine.anatomical_structure nervous system biology.protein Carcinoma Squamous Cell Immunohistochemistry Neural cell adhesion molecule Female business |
| Zdroj: | Human pathology. 31(4) |
| ISSN: | 0046-8177 |
| Popis: | Neural cell adhesion molecules (NCAM) are adhesion molecules expressed by neural and neuroendocrine tumors and a few biphasic tumors such as synovialosarcomas and breast phyllode tumors. To investigate NCAM expression in mesotheliomas, we studied 26 cases of epithelioid (n = 12), biphasic (n = 11), and sarcomatoid (n = 3) malignant mesotheliomas (MM), in comparison with normal mesothelium, and 50 primary non-small cell lung carcinomas (NSCLC) (25 adenocarcinomas [ADC] and 25 squamous cell carcinomas [SCC]), using electron microscopy as a gold standard for recognition of MM. NCAM reactivity using 123C3 antibody was compared with that of NE markers such as chromogranin A and synaptophysin. Although normal mesothelium remains negative, NCAM was expressed in 19 of 26 MM (73%) with a membranous staining on frozen or paraffin sections. In 6 of 12 epithelioid MM, the tumor cells expressed NCAM, whereas in 5 cases stromal fibroblasts showed a strong but focal staining. In 11 biphasic MM, 4 presented an NCAM reactivity of both epithelioid and spindle cell components, whereas in 7, only fusiform component was NCAM positive. Two of 3 sarcomatoid MM showed an NCAM expression. Chromogranin expression was never seen, whereas synaptophysin was noticed in 2 cases. No case of NSCLC showed membranous 123C3 staining, whereas 2 ADC weakly expressed synaptophysin. We conclude that NCAM expression in MM is reminiscent of its expression in mesoderm during fetal life and consistent with that reported in other biphasic tumors. These data show that NCAM expression occurs in 73% of MM, highly exceeding that observed in lung cancer. |
| Databáze: | OpenAIRE |
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