Novel non-benzimidazole chk2 kinase inhibitors
| Autor: | Anders Brunmark, Liming Huang, Kirsten L. Arienti, Kelly J. McClure, J. Guy Breitenbucher, Frank U. Axe, Jon Blevitt |
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| Rok vydání: | 2006 |
| Předmět: |
Models
Molecular Imidazopyridine Benzimidazole Molecular model medicine.drug_class Stereochemistry Clinical Biochemistry Pharmaceutical Science Radiation-Protective Agents Carboxamide Protein Serine-Threonine Kinases Biochemistry Structure-Activity Relationship chemistry.chemical_compound Drug Discovery medicine Protein kinase A Protein Kinase Inhibitors Molecular Biology biology Kinase Organic Chemistry Biological activity General Medicine Checkpoint Kinase 2 chemistry Enzyme inhibitor biology.protein Molecular Medicine Benzimidazoles |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 16:1924-1928 |
| ISSN: | 0960-894X |
| Popis: | In a recent paper, [Arienti, K. L.; Brunmark, A.; Axe, F. U.; McClure, K. M.; Lee, A.; Blevitt, J.; Neff, D. K.; Huang, L.; Crawford, S.; Chennagiri, R. P.; Karlsson, L.; Brietenbucher, J. G. J. Med. Chem.2005, 48, 1873], we described the discovery of a class of benzimidazole chk2 kinase inhibitors, exemplified by compound 1, which had radio-protective effects in human T-cells subjected to ionizing radiation. Here, a series of non-benzimidazole analogs intended to define the scope of the SAR about this new series of inhibitor, and allow for refinement of the binding model of these compounds to the chk2 kinase is described. |
| Databáze: | OpenAIRE |
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