Altered structure and functional connection in patients with classical trigeminal neuralgia
Autor: | Dharni Patel, Jen Tsung Yang, Yuan Hsiung Tsai, Ching Po Lin, Rui Yuan, Hsu-Huei Weng, Subhashini Chandrasekaran, Bharat B. Biswal |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2017 |
Předmět: |
Male
Time Factors Thalamus Inferior frontal gyrus Functional Laterality 03 medical and health sciences 0302 clinical medicine Trigeminal neuralgia Neural Pathways Image Processing Computer-Assisted Medicine Humans Radiology Nuclear Medicine and imaging 030212 general & internal medicine Prospective Studies Gray Matter Prefrontal cortex Research Articles Brain Mapping Radiological and Ultrasound Technology business.industry Putamen Ventral striatum Precentral gyrus Brain Anatomy Voxel-based morphometry Organ Size Middle Aged Trigeminal Neuralgia medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Neurology nervous system Female Neurology (clinical) business 030217 neurology & neurosurgery |
Zdroj: | Hum Brain Mapp |
Popis: | Classical trigeminal neuralgia (TN) is a specific type of neuropathic orofacial pain of which the plasticity of brain structure and connectivity have remained largely unknown. A total of 62 TN patients were included and referred to MRI scans. Voxel-based morphometry was used to analyze the change of gray matter volume. Resting-state functional imaging was used to analyze the connectivity between brain regions. The results showed gray matter volume reduction in components of the prefrontal cortex, precentral gyrus, cerebellar tonsil, thalamus, hypothalamus, and nucleus accumbens among right TN patient and in the inferior frontal gyrus, precentral gyrus, cerebellum, thalamus, ventral striatum, and putamen among left TN patients. The connections between the right superior frontal gyrus and right middle frontal gyrus were lower in right TN patients. The connection between the left precentral gyrus and the left superior frontal gyrus was lower while the connection between bilateral thalamus was higher in left TN patients. The changes of volume in bilateral thalamus of right TN patients and left ventral striatum of left TN patients, and the connectivity between bilateral thalamus of left TN patients were moderately correlated with pain duration. These findings suggest that brain regions such as the thalamus may not only be involved in processing of pain stimuli but also be important for the development of TN. The left hemisphere may be dominant in processing and modulation of TN pain signal. Chronification of TN induces volume changes in brain regions which are associated with emotional or cognitive modulation of pain. Hum Brain Mapp 39:609-621, 2018. © 2017 Wiley Periodicals, Inc. |
Databáze: | OpenAIRE |
Externí odkaz: |