Quantitative T2 Mapping of Knee Cartilage: Differentiation of Healthy Control Cartilage and Cartilage Repair Tissue in the Knee with Unloading—Initial Results
| Autor: | Stefan Marlovits, Siegfried Trattnig, Tallal C. Mamisch, Goetz H. Welsch, Lawrence M. White, S. Quirbach |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Cartilage Articular Male Pathology medicine.medical_specialty Adolescent Knee Joint Articular cartilage Chondrocyte Arthroscopy Chondrocytes Tissue engineering Image Processing Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging Prospective Studies Hyaluronic Acid Cartilage repair Analysis of Variance Wound Healing Tissue Engineering medicine.diagnostic_test business.industry Cartilage Regeneration (biology) Anatomy Middle Aged Magnetic Resonance Imaging Cross-Sectional Studies Treatment Outcome medicine.anatomical_structure Female business Wound healing |
| Zdroj: | Radiology. 254:818-826 |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | To prospectively determine on T2 cartilage maps the effect of unloading during a clinical magnetic resonance (MR) examination in the postoperative follow-up of patients after matrix-associated autologous chondrocyte transplantation (MACT) of the knee joint.Ethical approval for this study was provided by the local ethics commission, and written informed consent was obtained. Thirty patients (mean age, 35.4 years +/- 10.5) with a mean postoperative follow-up period of 29.1 months +/- 24.4 were enrolled. A multiecho spin-echo T2-weighted sequence was performed at the beginning (early unloading) and end (late unloading) of the MR examination, with an interval of 45 minutes. Mean and zonal region of interest T2 measurements were obtained in control cartilage and cartilage repair tissue. Statistical analysis of variance was performed.The change in T2 values of control cartilage (early unloading, 50.2 msec +/- 8.4; late unloading, 51.3 msec +/- 8.5) was less pronounced than the change in T2 values of cartilage repair tissue (early unloading, 51.8 msec +/- 11.7; late unloading, 56.1 msec +/- 14.4) (P = .024). The difference between control cartilage and cartilage repair tissue was not significant for early unloading (P = .314) but was significant for late unloading (P = .036). Zonal T2 measurements revealed a higher dependency on unloading for the superficial cartilage layer.Our results suggest that T2 relaxation can be used to assess early and late unloading values of articular cartilage in a clinical setting and that the time point of the quantitative T2 measurement affects the differentiation between native and abnormal articular cartilage. (c) RSNA, 2010. |
| Databáze: | OpenAIRE |
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