Plasma Potassium Response After Tromethamine (THAM) or Sodium Bicarbonate in the Acidotic Rabbit
| Autor: | Robert S. Howard, Jonathan H. Waters, Ivan K. Lesnik |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.medical_specialty
Tromethamine Sodium Potassium chemistry.chemical_element Blood Pressure Alkalies Buffers Pharmacology Random Allocation chemistry.chemical_compound medicine Animals Hypoxia Acidosis Analysis of Variance Sodium bicarbonate Lagomorpha biology business.industry Metabolic disorder Carbon Dioxide Hydrogen-Ion Concentration medicine.disease biology.organism_classification Surgery Disease Models Animal Sodium Bicarbonate Anesthesiology and Pain Medicine chemistry Linear Models Female Rabbits Hypernatremia medicine.symptom business |
| Zdroj: | Anesthesia & Analgesia. 83:789-792 |
| ISSN: | 0003-2999 |
| DOI: | 10.1097/00000539-199610000-00023 |
| Popis: | The purpose of this study was to evaluate the plasma potassium (K+) response after administration of tromethamine (THAM) or sodium bicarbonate (NaHCO3) in an acidotic rabbit model. Eighteen healthy, adult female New Zealand White rabbits were subjected to severe hypoxia until a base deficit of -10 mEq/L resulted. Rabbits were then randomized to receive THAM solution, NaHCO3, or no drug (control). The drug was administered over 2 min in quantities calculated to correct a base deficit of 10 or greater. Plasma K+ and sodium (Na+) were measured for 45 min after drug administration. No difference in K+ response was noted after THAM, NaHCO3, or no drug. In contrast, THAM resulted in significantly lower Na+ concentrations when compared to the NaHCO3 or the control group (P < 0.05). In this rabbit model, alkalinization after THAM administration results in K+ changes similar to those after NaHCO3. THAM should be considered when treating acidosis in patients where hypernatremia is a concern. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|