The morphology of xenotransplanted human breast carcinoma MX-1 growing in nude mice. A light and transmission electron microscopic study
| Autor: | Heinz J. Krammer, Andrés S. Mendoza, Wolfgang Kühnel, Matthias Krüger, M. Mentzel, T. Wagner, Christoph Weiss, G. J. Wiedemann |
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| Rok vydání: | 1995 |
| Předmět: |
Pathology
medicine.medical_specialty Nucleolus Transplantation Heterologous Mice Nude Connective tissue Breast Neoplasms Biology Cell Line Mice symbols.namesake Nerve Fibers Dermis Tumor Cells Cultured medicine Animals Humans Endoplasmic reticulum General Medicine Golgi apparatus Capillaries Transplantation Microscopy Electron medicine.anatomical_structure Cytoplasm symbols Ultrastructure Female Anatomy Developmental Biology |
| Zdroj: | Annals of Anatomy - Anatomischer Anzeiger. 177:3-10 |
| ISSN: | 0940-9602 |
| DOI: | 10.1016/s0940-9602(11)80122-6 |
| Popis: | The present investigation is concerned with the morphological features of the human breast carcinoma MX-1, transplanted subcutaneously into nude mice. Three weeks after transplantation the tumor tissue is clearly distinct from the dermis. Solid tumor cell groups are separated incompletely by thin connective tissue septa, giving rise to a lobular appearance. The tumor cells are characterized by very irregularly formed nuclei with three or more nucleoli. The cytoplasm of these cells displays some lysosomes, the cisternae of the rough endoplasmic reticulum, mitochondria and a variable number of ribosomes. The Golgi fields are frequently observed, particularly near the nucleus. The cells are connected to each other by desmosomes, which also persist during mitotic activity. Ductular formations can occasionally be seen. The ultrastructure of the blood vessels discloses the morphological features necessary for the regulation of blood flow. Capillaries present a sinusoidal aspect with distended and narrow lumina. Interruptions of the endothelial wall, however, were not observed. This morphological appearance was found in all the MX-1 tumors investigated, reflecting the stable growth of this tumor cell line in nude mice. |
| Databáze: | OpenAIRE |
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