Area of the cone interdigitation zone in healthy Chinese adults and its correlation with macular volume

Autor: Gezhi Xu, Ruiping Gu, Jiang Yi, Guohua Deng, Chunhui Jiang
Rok vydání: 2018
Předmět:
Adult
Male
China
medicine.medical_specialty
genetic structures
High variability
Posterior pole
Visual Acuity
Emmetropia
Correlation
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
lcsh:Ophthalmology
Optical coherence tomography
Ophthalmology
medicine
Humans
Macula Lutea
Outer nuclear layer (ONL)
Outer nuclear layer
Retrospective Studies
Optical coherence tomography (OCT)
medicine.diagnostic_test
business.industry
Chinese adults
Retinal
General Medicine
Middle Aged
Healthy Chinese adult
Healthy Volunteers
eye diseases
Cross-Sectional Studies
medicine.anatomical_structure
chemistry
lcsh:RE1-994
Retinal Cone Photoreceptor Cells
030221 ophthalmology & optometry
Ellipsoid zone (EZ)
Female
sense organs
business
Tomography
Optical Coherence
Cone interdigitation zone (IZ)
The cone interdigitation zone area
030217 neurology & neurosurgery
Research Article
Zdroj: BMC Ophthalmology
BMC Ophthalmology, Vol 18, Iss 1, Pp 1-6 (2018)
ISSN: 1471-2415
DOI: 10.1186/s12886-018-0862-7
Popis: Background Numerous studies have suggested that the integrity of the cone interdigitation zone (IZ) could be considered to be a marker of photoreceptor damage and its recovery. However, little is known about the IZ in healthy eyes. Our present study was to measure the cone IZ area by optical coherence tomography (OCT), and determine its distribution in healthy adults. Methods This was a cross-sectional non-interventional study. We involved a group of 158 emmetropic or low myopic (from −3D to + 0.5D) eyes in 97 healthy adult volunteers. All subjects underwent thorough ophthalmologic examinations and the posterior pole was scanned by OCT. The cone IZ area in healthy adults and its correlation with macular volume and other factors was analyzed. Results The cone IZ was visible and clear in all 158 eyes, and the IZ area was successfully measured by 6 radical scans centered on the fovea. The mean IZ area was 30.22 ± 12.70 mm2, and ranged from 5.91 to 57.47 mm2. The IZ area exhibited a normal distribution (P = 0.635) with 95% confidence interval of 28.06–32.29 mm2. The IZ area was significantly correlated with the retinal and outer nuclear layer (ONL) volumes within the macula. Conclusions The cone IZ area could be measured using a commercially available OCT system. The IZ area showed high variability among healthy adults, and this might be related to the variability in the photoreceptor distribution in healthy adults. Electronic supplementary material The online version of this article (10.1186/s12886-018-0862-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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