Utility of a Sputum Antigen Detection Test in Pneumococcal Pneumonia and Lower Respiratory Infectious Disease in Adults
| Autor: | Osamu Kosaka, Noboru Takayanagi, Toyomitsu Sawai, Kiyoyasu Fukushima, Tadashi Ishida, Yuichi Inoue, Koichi Izumikawa, Yasuhito Higashiyama, Chikara Nakahama, Yasuhiko Nishioka, Nobuki Aoki, Tomoyuki Kakugawa, Shigeru Kohno, Shigeki Nakamura, Mitsuhide Ohmichi, Kunihiko Yoshimura |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.disease_cause Gastroenterology Sensitivity and Specificity Sputum culture law.invention Japan law Internal medicine Lower respiratory tract infection Streptococcus pneumoniae Internal Medicine medicine Humans Respiratory Tract Infections Immunoassay Antigens Bacterial medicine.diagnostic_test Respiratory tract infections business.industry Sputum General Medicine Middle Aged Pneumonia Pneumococcal medicine.disease Community-Acquired Infections Gram staining Early Diagnosis Pneumococcal pneumonia Immunology Phenazines Female Gentian Violet Reagent Kits Diagnostic medicine.symptom business |
| Zdroj: | Internal medicine (Tokyo, Japan). 54(22) |
| ISSN: | 1349-7235 |
| Popis: | OBJECTIVE To compare the utility of Gram staining, a urinary antigen detection kit and a sputum antigen detection kit were examined for the rapid and early detection of pneumococcal pneumonia and lower respiratory infectious diseases. METHODS A newly developed sputum pneumococcal antigen detection kit (RAPIRUN), Gram staining, and urinary antigen detection kit (BinaxNOW) were comparatively evaluated for their ability to detect Streptococcus pneumoniae in patients with pneumonia or lower respiratory tract infection. Sputum culture results were used as a standard for comparison. Furthermore, the pneumococcus-positive rates in culture and rapid tests were compared using polymerase chain reaction (PCR) as a reference. RESULTS Of the 169 patients studied, 54 (32.0%) tested positive for S. pneumoniae in culture. S. pneumoniae detection sensitivities for Gram staining, RAPIRUN, and BinaxNOW were 75.9%, 90.7%, and 53.7%, respectively; thus, RAPIRUN had a significantly higher sensitivity than BinaxNOW (p |
| Databáze: | OpenAIRE |
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