Hypercholesterolemia and Lifetime Risk of Coronary Heart Disease in the General Japanese Population: Results from the Suita Cohort Study
| Autor: | Yoshihiro Kokubo, Yoshihiro Miyamoto, Nahid Rumana, Makoto Watanabe, Daisuke Sugiyama, Aya Higashiyama, Fahmida Yeasmin, Tanvir Chowdhury Turin, Misa Takegami, Tomonori Okamura |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Hypercholesterolemia Coronary Disease Disease 030204 cardiovascular system & hematology Cohort Studies 03 medical and health sciences 0302 clinical medicine Sex Factors Japan Risk Factors Internal medicine Internal Medicine Medicine Humans Low-density lipoprotein cholesterol Disease burden Triglycerides Aged business.industry Public health Biochemistry (medical) Cholesterol HDL Age Factors Coronary heart diseases Cholesterol LDL Japanese population Middle Aged Lifetime risk Confidence interval Coronary heart disease Non-high-density lipoprotein cholesterol lipids (amino acids peptides and proteins) Original Article Female Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery Cohort study |
| Zdroj: | Journal of Atherosclerosis and Thrombosis |
| ISSN: | 1880-3873 1340-3478 |
| Popis: | Aim Lifetime risk (LTR) is a measure of disease burden, which presents the probability of occurrence of a specific disease in the remaining lifetime of a group of people for a given index age. This measure is useful for presenting the risk dynamics of a disease at the population level, which constitutes important public health information toward prevention. To date, there have been no studies investigating the LTR for coronary heart diseases (CHDs) in relation to hypercholesterolemia in Asian populations. Therefore, we estimated the LTR of CHDs according to serum low-density lipoprotein cholesterol (LDL-C). Methods The participants included in this study were 2,559 men and 2,848 women, enrolled in the Suita Cohort Study of urban residents followed up from 1989 to 2007 for a total of 69,823 person-years. We estimated the sex- and index-age-specific LTR for the first CHD event among participants with or without hypercholesterolemia (LDL-C ≥ 160 mg/dL), accounting for the competing risk for mortality. Results For men with hypercholesterolemia, the LTR was 47.2% (95% confidence interval [CI]: 29.3-65.1%) and 44.5% (95% CI: 21.4-68.5%) for those aged 45 and 75, respectively. The LTRs of women with hypercholesterolemia were also higher than of those without hypercholesterolemia. However, their LTRs were lower for all index ages compared to men. These results did not differ for hypercholesterolemia defined by non-high-density lipoprotein cholesterol. Conclusions The presence of hypercholesterolemia increases the LTR for CHDs in the Japanese population, especially in men. This estimate can be used in preventive knowledge translation efforts at the population level. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|