Pentoxifylline, tocopherol, and clodronate for the treatment of mandibular osteoradionecrosis: a systematic review
| Autor: | Míriam Martos-Fernández, Coro Bescós-Atín, Manel Saez-Barba, Jose María Balibrea-del-Castillo, Albert Estrugo-Devesa, José López-López |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Oncology
Vitamin medicine.medical_specialty Combination therapy Osteoradionecrosis MEDLINE Tocopherols Pathology and Forensic Medicine Pentoxifylline 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pharmacotherapy Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Mandibular Diseases Tocopherol business.industry 030206 dentistry medicine.disease Clinical trial Drug Combinations chemistry Head and Neck Neoplasms 030220 oncology & carcinogenesis Surgery Oral Surgery Clodronic Acid business medicine.drug |
| Zdroj: | Oral surgery, oral medicine, oral pathology and oral radiology. 125(5) |
| ISSN: | 2212-4411 |
| Popis: | Objective The purpose of this study was to evaluate the healing benefit provided by the antioxidant and antifibrotic properties of pentoxifylline–tocopherol or pentoxifylline–tocopherol–clodronate in combination therapy for osteoradionecrosis. Study Design We searched for relevant reports in PubMed by using a combination of “osteoradionecrosis” and the following keywords: “pentoxifillyne,” “tocopherol,” “vitamin E,” or “clodronate.” We considered articles in English or Spanish, with no limitations on the publication date. Results The combination of pentoxifylline plus tocopherol with or without clodronate was found to be effective for the treatment of mandibular osteoradionecrosis, although data were generally scarce and mostly came from retrospective case series. Conclusions This drug therapy is well tolerated and could be promising for the treatment of mandibular osteoradionecrosis, but prospective randomized controlled clinical trials are needed for further clarification. |
| Databáze: | OpenAIRE |
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