| Autor: |
ANM Nazmul H. Khan, Tiffany R. Emmons, William J. Magner, Emad Alqassim, Kelly L. Singel, Jason Ricciuti, Kevin H. Eng, Kunle Odunsi, Thomas B. Tomasi, Kelvin Lee, Scott I. Abrams, Circe Mesa, Brahm H. Segal |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Cancer immunology, immunotherapy : CII. 71(10) |
| ISSN: |
1432-0851 |
| Popis: |
The ovarian tumor microenvironment (TME) is characterized by the accumulation of immunosuppressive tumor-associated macrophages (TAMs) and granulocytic cells. Very small size particles (VSSP), comprised of the ganglioside NAcGM3 and Neisseria meningitidis derived outer membrane vesicles, is being developed as a nanoparticulated modulator of innate immunity. Prior studies have shown that VSSP enhanced antigen-specific cytotoxic T cell responses and reduced the suppressive phenotype of splenic granulocytic cells in tumor-bearing mice. Here, we hypothesized that intraperitoneal VSSP would modify myeloid cell accumulation and phenotypes in the ovarian TME and abrogate suppressor function of TAMs and tumor-associated granulocytic cells. In the ID8 syngeneic model of epithelial ovarian cancer, VSSP reduced peritoneal TAMs and induced M1-like polarization in TAMs. In addition, VSSP stimulated peritoneal inflammation characterized by increased granulocytes and monocytes, including inflammatory monocytic cells. VSSP treatment resulted in peritoneal TAMs and granulocytic cells being less suppressive of ex vivo stimulated CD8 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink