Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists--Increasing selectivity over hERG

Autor:	Nick K. Kim, José Méndez-Andino, John August Wos, Sean R. Klopfenstein, David C. Ackley, Kenneth M. Meyers, Jennifer L. Paris, Ofer Reizes, Jerry K. Holbert, Maria C. Mitchell, Mumin Rashid Naeem, Scott W. Mittelstadt, X. Eric Hu
Rok vydání:	2006
Předmět:	congenital hereditary and neonatal diseases and abnormalities ERG1 Potassium Channel medicine.drug_class Stereochemistry Clinical Biochemistry hERG Pharmaceutical Science Carboxamide Mianserin Naphthalenes Biochemistry Chemical synthesis chemistry.chemical_compound Structure-Activity Relationship Drug Discovery medicine Potassium Channel Blockers Receptor Serotonin 5-HT2C Structure–activity relationship Humans cardiovascular diseases Receptors Somatostatin Ergolines Molecular Biology Biphenyl biology Chemistry Organic Chemistry Biphenyl Compounds Nutritional status Ether-A-Go-Go Potassium Channels biology.protein Molecular Medicine Indicators and Reagents Serotonin Antagonists Selectivity hormones hormone substitutes and hormone antagonists
Zdroj:	Bioorganicmedicinal chemistry letters. 17(3)
ISSN:	0960-894X
Popis:	Aminomethyl tetrahydronaphthalene biphenyl carboxamide MCH-R1 antagonists with greater selectivity over hERG were identified. SAR studies addressing two distinct alternatives for structural modifications leading to improve hERG selectivity are described.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61f0579019ef8767dbea6642afb07fcb https://pubmed.ncbi.nlm.nih.gov/17107791 Zobrazit plný text záznamu Full Text from ScienceDirect