The Role of Dapagliflozin in the Management of Heart Failure: An Update on the Emerging Evidence
| Autor: | Manasvi Gupta, Gregg C. Fonarow, Raktim K. Ghosh, Gaurav Manek, Shiavax J. Rao |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Kidney Disease Management of heart failure DECLARE-TIMI Clinical Trials and Supportive Activities Review Cardiovascular law.invention chemistry.chemical_compound Clinical pathway Randomized controlled trial law Clinical Research medicine Pharmacology (medical) Oncology & Carcinogenesis General Pharmacology Toxicology and Pharmaceutics Dapagliflozin Intensive care medicine Chemical Health and Safety Ejection fraction business.industry DEFINE-HF DAPA-CKD General Medicine Guideline HFrEF dapagliflozin medicine.disease Heart Disease Good Health and Well Being chemistry Heart failure Public Health and Health Services business Safety Research DAPA-HF Kidney disease |
| Zdroj: | Therapeutics and Clinical Risk Management |
| Popis: | The burden and cost of heart failure management, primarily in the form of hospitalization in the setting of decompensated heart failure, continue to be some of the biggest clinical challenges in cardiovascular medicine. In recently published randomized controlled trials, including DAPA-HF, sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin was shown to reduce hospitalization from heart failure or mortality associated with cardiovascular causes, when added to existing guideline-directed medical therapy. The American College of Cardiology (ACC) released a Clinical Pathway guideline that recommends the use of dapagliflozin in clinical management of heart failure, with or without diabetes. Furthermore, the results of the DAPA-CKD trial broaden the utility of dapagliflozin as a therapeutic option in patients with advanced kidney disease. In this article, the authors explore the existing evidence on dapagliflozin in heart failure with reduced ejection fraction and highlight the need for further research on uses of dapagliflozin in the world of heart failure. |
| Databáze: | OpenAIRE |
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