Visual brain plasticity induced by central and peripheral visual field loss

Autor: Christophe Habas, Norman Sabbah, Michel Thiebaut de Schotten, José-Alain Sahel, Avinoam B. Safran, Leonardo Cerliani, Nicolae Sanda, Colas N. Authié
Přispěvatelé: Institut de la Vision, Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts (CHNO), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Fondation Ophtalmologique Adolphe de Rothschild [Paris], HAL UPMC, Gestionnaire, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Adult Psychiatry
Rok vydání: 2018
Předmět:
Adult
Male
0301 basic medicine
Histology
Adolescent
genetic structures
Resting-state cortical entropy
[SDV]Life Sciences [q-bio]
Biology
Cortical thickness
Macular Degeneration
Young Adult
03 medical and health sciences
0302 clinical medicine
Neuroplasticity
Retinitis pigmentosa
Tunnel vision
medicine
Humans
Stargardt Disease
Visual Cortex
Brain Mapping
Neuronal Plasticity
Cytoarchitectonic areas
Echo-Planar Imaging
General Neuroscience
Stargardt macular degeneration
Human brain
Middle Aged
medicine.disease
Central visual field loss
eye diseases
Visual field
[SDV] Life Sciences [q-bio]
030104 developmental biology
medicine.anatomical_structure
Visual cortex
Visual plasticity
Peripheral vision
Peripheral visual field loss
Female
Original Article
Visual Fields
Anatomy
medicine.symptom
Neuroscience
030217 neurology & neurosurgery
Zdroj: Brain Structure and Function
Brain Structure and Function, Springer Verlag, 2018, 223 (7), pp.3473-3485. ⟨10.1007/s00429-018-1700-7⟩
Brain Structure & Function
Brain Structure and Function, 2018, 223 (7), pp.3473-3485. ⟨10.1007/s00429-018-1700-7⟩
Brain structure & function, 223(7), 3473-3485. Springer Verlag
ISSN: 1863-2661
1863-2653
DOI: 10.1007/s00429-018-1700-7
Popis: Disorders that specifically affect central and peripheral vision constitute invaluable models to study how the human brain adapts to visual deafferentation. We explored cortical changes after the loss of central or peripheral vision. Cortical thickness (CoTks) and resting-state cortical entropy (rs-CoEn), as a surrogate for neural and synaptic complexity, were extracted in 12 Stargardt macular dystrophy, 12 retinitis pigmentosa (tunnel vision stage), and 14 normally sighted subjects. When compared to controls, both groups with visual loss exhibited decreased CoTks in dorsal area V3d. Peripheral visual field loss also showed a specific CoTks decrease in early visual cortex and ventral area V4, while central visual field loss in dorsal area V3A. Only central visual field loss exhibited increased CoEn in LO-2 area and FG1. Current results revealed biomarkers of brain plasticity within the dorsal and the ventral visual streams following central and peripheral visual field defects. Electronic supplementary material The online version of this article (10.1007/s00429-018-1700-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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