TREATMENT PATTERNS IN PATIENTS WITH CHRONIC-PHASE CHRONIC MYELOID LEUKAEMIA IN ROUTINE CLINICAL PRACTICE: THE SIMPLICITY ITALIAN POPULATION
| Autor: | Massimo Breccia, Nicola Di Renzo, Fabio Stagno, Raffaele Porrini, Ginny P Sen, Francesco De Solda, Mariella D'Adda, Ester Pungolino, Elisabetta Abruzzese, Alberto Bosi, Fabrizio Pane, Federica Sorà, Ester Orlandi, Fabiana Gentilini, Anna Marina Liberati, Carlo Gambacorti-Passerini |
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| Přispěvatelé: | Abruzzese, E., Bosi, A., Breccia, M., D'Adda, M., Renzo, N. D., Liberati, A. M., Porrini, R., Orlandi, E. M., Pane, F., Pungolino, E., Sora, F., Stagno, F., Sen, G. P., Gentilini, F., De Solda, F., Gambacorti-Passerini, C., Abruzzese, E, Bosi, A, Breccia, M, D'Adda, M, Renzo, N, Liberati, A, Porrini, R, Orlandi, E, Pane, F, Pungolino, E, Sora, F, Stagno, F, Sen, G, Gentilini, F, De Solda, F, Gambacorti-Passerini, C |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pediatrics medicine.medical_specialty media_common.quotation_subject Population Response Monitoring 03 medical and health sciences 0302 clinical medicine MED/15 - MALATTIE DEL SANGUE Medicine Routine clinical practice Chronic-Phase Chronic Myeloid Leukaemia Simplicity education media_common TKI switching pattern education.field_of_study lcsh:RC633-647.5 business.industry Imatinib lcsh:Diseases of the blood and blood-forming organs Hematology respiratory tract diseases Dasatinib Settore MED/15 - MALATTIE DEL SANGUE 030104 developmental biology Infectious Diseases Italy Nilotinib TKI switching patterns SIMPLICITY 030220 oncology & carcinogenesis Cohort Original Article Observational study business medicine.drug |
| Zdroj: | Mediterranean Journal of Hematology and Infectious Diseases Mediterranean Journal of Hematology and Infectious Diseases, Vol 11, Iss 1 (2019) |
| ISSN: | 2035-3006 |
| Popis: | Background and Objectives While tyrosine kinase inhibitors (TKIs) have transformed CP-CML management, limited data exist on their use in clinical practice. Methods SIMPLICITY (NCT01244750) is an observational study in CP-CML patients, exploring first‑line (1L) TKI use and management patterns in the US and Europe. Over half of the patients recruited in Europe are from Italy (n=266). This is an analysis of the Italian cohort and a comparison with the rest of the European SIMPLICITY population. Baseline demographic, factors influencing choice of first-line TKI, response monitoring patterns and predictors of monitoring, and treatment interruptions, discontinuations and switching by index TKIs are presented for the Italian cohort in the first year of treatment and compared with that for the overall European SIMPLICITY cohort. Results Italian patients received 1L imatinib (IM; retrospective [(n=31]; prospective [n=106]), dasatinib (DAS; n=56) or nilotinib (NIL; n=73). Documented cytogenetic response monitoring by 12 months was lower than expected, but almost all patients had documented molecular response monitoring. Fewer patients discontinued first-line TKI by 12 months in Italy compared with the rest of the European SIMPLICITY population (p=0.003). Of those with ≥12 months follow-up since start of 1L TKI, only 7.1% (n=19) of Italian patients switched to a second-line TKI, a third less than in the rest of the European SIMPLICITY population. Of interest, intolerance as opposed to resistance, was the main reason for switching. Conclusion This analysis provides valuable insights into management and treatment patterns in Italian patients with CML within routine clinical practice. |
| Databáze: | OpenAIRE |
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