Local Renal Delivery of a Natriuretic Peptide
| Autor: | John C. Burnett, Lynn K. Harstad, Horng H. Chen, Alessandro Cataliotti, Fernando L. Martin, John A. Schirger |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Kidney medicine.drug_class business.industry Urinary system Diuresis Renal function urologic and male genital diseases Brain natriuretic peptide medicine.disease Natriuresis Endocrinology medicine.anatomical_structure Internal medicine Heart failure cardiovascular system medicine Natriuretic peptide Cardiology cardiovascular diseases Cardiology and Cardiovascular Medicine business human activities hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of the American College of Cardiology. 53:1302-1308 |
| ISSN: | 0735-1097 |
| Popis: | Objectives The purpose of this study was to test the hypothesis that local renal delivery of B-type natriuretic peptide (BNP) will overcome renal resistance to BNP without systemic hypotension. Background BNP has vasodilating, natriuretic, and renin-inhibiting properties. In overt heart failure (HF), there is development of renal resistance to BNP. Methods We defined the cardiorenal and humoral effects of systemic (n = 6) or local renal (n = 7) administration of canine BNP (0.01 μg/kg/min) in 2 separate groups of dogs with pacing-induced subacute overt HF complicated by renal dysfunction. We used a commercially available small (3.1-F) bifurcated renal catheter (FlowMedica Inc., Fremont, California) for direct bilateral infusion of BNP into both renal arteries. Results With systemic BNP at this clinically used dose (without the bolus), urine flow increased, but there was only a trend for an increase in urinary sodium excretion and glomerular filtration rate (GFR). In contrast, local renal delivery of BNP resulted in significant diuresis and natriuresis and an increase in GFR. These diuretic and natriuretic responses were greater with local renal BNP compared with systemic BNP, and were associated with increased delivery of BNP to the renal tubules as evident by a greater urinary BNP excretion resulting in a decrease in distal reabsorption of sodium. Importantly, local renal BNP did not result in a significant decrease in mean arterial pressure that was observed with systemic BNP. Conclusions We conclude that local renal BNP delivery is a novel strategy that may overcome renal assistance to BNP in overt HF by increasing local delivery of BNP to the renal tubules. |
| Databáze: | OpenAIRE |
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