Clinical features of and risk factors for normoalbuminuric diabetic kidney disease in hospitalized patients with type 2 diabetes mellitus: a retrospective cross-sectional study

Autor: Feng-Xiu Jiang, Xin-Jie Lin, Qi Dai, Nan Chen, Ling Zeng, Ze-Yuan Lu, Xiong-Jie Zhuang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Adult
Male
China
medicine.medical_specialty
Cross-sectional study
Endocrinology
Diabetes and Metabolism
030232 urology & nephrology
Renal function
030204 cardiovascular system & hematology
Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Diabetes mellitus
Type 2 diabetes mellitus
medicine
Humans
Diabetic Nephropathies
Stroke
Macrovascular complications
Aged
Retrospective Studies
Normoalbuminuric diabetic kidney disease
Inpatients
business.industry
Type 2 Diabetes Mellitus
General Medicine
Middle Aged
medicine.disease
RC648-665
Confidence interval
Cross-Sectional Studies
Logistic Models
Diabetes Mellitus
Type 2
chemistry
Risk factors
Albuminuria
Female
Glycated hemoglobin
medicine.symptom
business
Research Article
Glomerular Filtration Rate
Zdroj: BMC Endocrine Disorders, Vol 21, Iss 1, Pp 1-9 (2021)
BMC Endocrine Disorders
ISSN: 1472-6823
Popis: Background Normoalbuminuric diabetic kidney disease (NADKD) is a newly defined DKD, the clinical features and pathogenesis for which are still being understood. This study aimed to investigate the features and risk factors for NADKD in patients with type 2 diabetes mellitus (T2DM). Methods A retrospective cross-sectional study was conducted. The related clinical and laboratory data of patients with T2DM hospitalized between August 2012 and January 2020 were collected for statistical analysis. We classified the patients with T2DM into four groups on the basis of the presence or absence of albuminuria and reduced estimated glomerular filtration rate (eGFR). Analysis of variance, the Kruskal–Wallis test, and the chi-square test were used to compare the groups. Binary logistic regression analyses with a forward stepwise method were performed to explore the risk factors for renal dysfunction in hospitalized patients with normoalbuminuric T2DM. Results Among the 1620 patients evaluated, 500 (30.9%) had DKD, of which 9% had NADKD. The prevalence of stroke, cardiovascular events, carotid plaque, and peripheral arterial disease in NADKD was significantly higher than in a non-DKD control group (normoalbuminuric T2DM patients with eGFR of ≥60 ml/min/1.73 m2). Regression analyses revealed that three significant independent factors were associated with NADKD: age (OR = 1.089, confidence interval [CI] 95% [1.055–1.123], p p = 0.011), and glycated hemoglobin (HbA1c; OR = 0.839, CI 95% [0.716–0.983], p = 0.03). Conclusions NADKD is mainly associated with macrovascular rather than microvascular complications. NADKD is more common in patients with normoalbuminuric T2DM with older age, previous use of RASIs, and good glycemic control.
Databáze: OpenAIRE
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