Obstructive sleep apnea in Arnold-Chiari malformation treated with acetazolamide
| Autor: | Hugo Lagercrantz, P Johnson, J Milerad |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Meningomyelocele
Stridor Hypoxemia Sleep Apnea Syndromes medicine Humans business.industry Respiration Infant Apnea General Medicine Carbon Dioxide medicine.disease Arnold-Chiari Malformation Hypoventilation Acetazolamide Oxygen Obstructive sleep apnea Control of respiration Anesthesia Pediatrics Perinatology and Child Health Breathing Female medicine.symptom business Hydrocephalus medicine.drug |
| Zdroj: | Acta Paediatrica. 81:609-612 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/j.1651-2227.1992.tb12311.x |
| Popis: | We studied respiratory patterns and transcutaneous gas pressures in two infants with Arnold-Chiari type II malformation referred to us due to repeated episodes of stridor and cyanosis. During both active and quiet sleep, respiration was irregular and absent or inverse thoracic breathing movements and frequent decreases in oxygen saturation to below 80% were observed. When breathing air with 2% CO2 or when given acetazolamide 10 mg/kg, chest wall movements normalized and oxygenation increased to near normal levels. After three months of treatment with acetazolamide 20 mg/kg/24 h no further episodes of hypoventilation or hypoxemia were observed and further treatment could be discontinued. We conclude that stimulation of respiration by CO2 or by acetazolamide appears to recruit chest wall muscles and promote upper airway patency in Arnold-Chiari malformation. A treatment trial with acetazolamide seems justifiable in these infants when respiratory problems are present. |
| Databáze: | OpenAIRE |
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