Comparative evaluation of the effects of tranexamic acid and low-dose aprotinin on post-valvular heart surgery bleeding and allogenic transfusion
| Autor: | Mojtaba Mansouri, Gholamreza Massoumi, Babak Ghavami, Keivan Bagheri, Mohammadali Attary |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Blood transfusion medicine.medical_treatment Iran Postoperative Hemorrhage Risk Assessment Hemostatics law.invention Aprotinin Double-Blind Method Risk Factors law medicine Humans Blood Transfusion Prospective Studies Heart Valve Prosthesis Implantation Analysis of Variance business.industry Original Articles Middle Aged medicine.disease Heart Valves Intensive care unit Surgery Bleeding diathesis Treatment Outcome Tranexamic Acid Respiratory failure Chest Tubes Anesthesia Prothrombin Time Drainage Partial Thromboplastin Time Fresh frozen plasma Cardiology and Cardiovascular Medicine Packed red blood cells business Tranexamic acid medicine.drug |
| Zdroj: | Interactive CardioVascular and Thoracic Surgery. 15:23-27 |
| ISSN: | 1569-9285 1569-9293 |
| DOI: | 10.1093/icvts/ivs114 |
| Popis: | Bleeding diathesis and allogenic transfusion after complex heart surgery, such as heart valve surgery, may result in complications such as transfusion reaction, viral infection, postoperative infection, haemodynamic disturbance, prolonged stay in the intensive care unit and hospital, renal and respiratory failure and mortality. In this prospective, double-blind, randomized, placebo-controlled clinical trial, 90 patients were randomly divided into three groups: aprotinin, tranexamic acid and control. Chest-tube drainage, transfusion requirements and renal and neurological complications were evaluated. We found that chest-tube drainage during the first (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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