Exhaled Breath Profiling Enables Discrimination of Chronic Obstructive Pulmonary Disease and Asthma
| Autor: | Selma B. de Nijs, Erica Dijkers, D. Cheung, Albert C. Roldaan, Elisabeth H. Bel, Marc P. van der Schee, Aeilko H. Zwinderman, Peter J. Sterk, Niki Fens |
|---|---|
| Přispěvatelé: | Pulmonology, APH - Amsterdam Public Health, Epidemiology and Data Science, Other departments, AII - Amsterdam institute for Infection and Immunity |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Adolescent Cross-sectional study Critical Care and Intensive Care Medicine Gastroenterology Pulmonary Disease Chronic Obstructive Young Adult Adrenal Cortex Hormones Forced Expiratory Volume Intensive care Internal medicine Humans Medicine Nose Aged Asthma Aged 80 and over Volatile Organic Compounds COPD Electronic nose business.industry Smoking Respiratory disease Reproducibility of Results Exhalation Middle Aged medicine.disease Surgery respiratory tract diseases Cross-Sectional Studies medicine.anatomical_structure Breath Tests Female business Biomarkers |
| Zdroj: | American journal of respiratory and critical care medicine, 180(11), 1076-1082. American Thoracic Society |
| ISSN: | 1073-449X |
| DOI: | 10.1164/rccm.200906-0939oc |
| Popis: | Rationale Chronic obstructive pulmonary disease (COPD) and asthma can exhibit overlapping clinical features. Exhaled air contains volatile organic compounds (VOCs) that may qualify as noninvasive biomarkers. VOC profiles can be assessed using integrative analysis by electronic nose, resulting in exhaled molecular fingerprints (breathprints). Objectives: We hypothesized that breathprints by electronic nose can discriminate patients with COPD and asthma. Methods: Ninety subjects participated in a cross-sectional study: 30 patients with COPD (age, 61.6+/-9.3 years; FEV1, 1.72+/-0.69 L), 20 patients with asthma (age, 35.4+/-15.1 years; FEV1, 3.32+/-0.86 L), 20 nonsmoking control subjects (age, 56.7+/-9.3 years; FEV1, 3.44+/-0.76 L), and 20 smoking control subjects (age, 56.1+/-5.9 years; FEV1, 3.58+/-0.78). After 5 minutes of tidal breathing through an inspiratory VOC filter, an expiratory vital capacity was collected in a Tedlar bag and sampled by electronic nose. Breathprints were analyzed by discriminant analysis on principal component reduction resulting in cross-validated accuracy values (accuracy). Repeatability and reproducibility were assessed by measuring samples in duplicate by two devices. Measurements and Main Results: Breathprints from patients with asthma were separated from patients with COPD (accuracy 96%; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|