Temperature-Controlled Chalcogenation and Chalcogenocyanation of Imidazopyridines in Water under Transition Metal-Free Conditions

Autor:	Xinju Zhu, Yuting Xue, Wannian Liu, Xin-Qi Hao, Yu-Shen Zhu, Mao-Ping Song
Rok vydání:	2020
Předmět:	Imidazopyridine Aqueous medium Transition metal 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry Photochemistry 01 natural sciences 0104 chemical sciences Catalysis
Zdroj:	The Journal of Organic Chemistry. 85:9106-9116
ISSN:	1520-6904 0022-3263
Popis:	A sustainable and transition metal-free approach for C3 chalcogenation and chalcogenocyanation of imidazopyridines with KXCN (X = S or Se) has been developed under mild conditions. Importantly, this reaction was performed in the presence of catalytic iodine in aqueous medium, which afforded either chalcogenated or chalcogenocyanated imidazopyridines under temperature control. The current protocol featured a broad substrate scope, transition metal-free and organic solvent-free conditions, operational convenience, and gram-scale production.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ebece10ae13a0a98724a7d5bd2d3e5 https://doi.org/10.1021/acs.joc.0c01035 Zobrazit plný text záznamu