Photodynamic therapy with chlorin e6. A morphologic study of tumor damage efficiency in experiment
| Autor: | I.N. Zhuravkin, E.A. Zhavrid, A.V. Furmanchuk, G.A. Kostenich |
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| Rok vydání: | 1991 |
| Předmět: |
Pathology
medicine.medical_specialty Radiation-Sensitizing Agents Necrosis Porphyrins Cell Survival medicine.medical_treatment Intraperitoneal injection Biophysics Photodynamic therapy chemistry.chemical_compound Optics In vivo medicine Animals Radiology Nuclear Medicine and imaging Evans Blue Radiation Radiological and Ultrasound Technology Chlorophyllides business.industry Chemistry Lasers Histology Phototherapy medicine.disease Rats Vital stain Sarcoma Sarcoma Experimental medicine.symptom business |
| Zdroj: | Journal of photochemistry and photobiology. B, Biology. 11(3-4) |
| ISSN: | 1011-1344 |
| Popis: | Morphological changes in rat sarcoma M-1 after photodynamic treatment with chlorin e6 were studied. The frequency of necrosis appearance and the depth of its spreading in tumor tissue were evaluated after intraperitoneal injection of chlorin e6 in doses of 1-10 mg kg-1 and subsequent irradiation by a krypton laser with light energy density 22.5-135 J cm-2, using the method of vital staining with Evans blue. It was found that the antitumoral effect of photodynamic treatment was strengthened by increasing the dose of the agent and light and reduced by increasing the time interval between chlorin e6 injection and light irradiation. The treatment being given in the parameters mentioned produced a depth of tumor necrosis which varied from 4.0 mm to 16.6 mm. The mechanisms of tumor tissue damage after photodynamic treatment in vivo are discussed. |
| Databáze: | OpenAIRE |
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