Computational modeling of aberrant electrical activity following remuscularization with intramyocardially injected pluripotent stem cell-derived cardiomyocytes
| Autor: | Seth H. Weinberg, Jialiu A Liang, Joseph K. Yu, Natalia A. Trayanova |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pluripotent Stem Cells
Junctional coupling Ischemic cardiomyopathy Chemistry Ephaptic coupling Sodium channel Myocardium digestive oral and skin physiology Gap junction Cell Differentiation digestive system digestive system diseases Article Cell biology Cell therapy Voltage dependence Computer Simulation Myocytes Cardiac Cardiology and Cardiovascular Medicine Induced pluripotent stem cell Molecular Biology |
| Zdroj: | J Mol Cell Cardiol |
| Popis: | Acute engraftment arrhythmias (EAs) remain a serious complication of remuscularization therapy. Preliminary evidence suggests that a focal source underlies these EAs stemming from the automaticity of immature pluripotent stem cell-derived cardiomyocytes (PSC-CMs) in nascent myocardial grafts. How these EAs arise though during early engraftment remains unclear. In a series of in silico experiments, we probed the origin of EAs—exploring aspects of altered impulse formation and altered impulse propagation within nascent PSC-CM grafts and at the host-graft interface. To account for poor gap junctional coupling during early PSC-CM engraftment, the voltage dependence of gap junctions and the possibility of ephaptic coupling were incorporated. Inspired by cardiac development, we also studied the contributions of another feature of immature PSC-CMs, circumferential sodium channel (NaCh) distribution in PSC-CMs. Ectopic propagations emerged from nascent grafts of immature PSC-CMs at a rate of |
| Databáze: | OpenAIRE |
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