A Case of Primary Cutaneous CD56+, TdT+, CD4+, Blastic NK-Cell Lymphoma in a 19-year-old Woman
| Autor: | Jee Ho Choi, Jooryung Huh, Jai Kyoung Koh, Kyung Jeh Sung, Kee Chan Moon, Sung Eun Chang, Hae Jung Choi |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Skin Neoplasms Dermatology Biology Blastoid Virus Germline Immunophenotyping Pathology and Forensic Medicine Natural killer cell DNA Nucleotidylexotransferase immune system diseases hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols medicine Humans Lymphoblastic lymphoma Blastic NK cell lymphoma General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease biology.organism_classification Immunohistochemistry CD56 Antigen Lymphoma Killer Cells Natural Treatment Outcome medicine.anatomical_structure CD4 Antigens Female |
| Zdroj: | The American Journal of Dermatopathology. 24:72-75 |
| ISSN: | 0193-1091 |
| DOI: | 10.1097/00000372-200202000-00015 |
| Popis: | The classification of blastic or blastoid natural killer (NK)-cell lymphoma is controversial. Reports of primary cutaneous blastic CD56+ NK-cell lymphoma are rare, which necessitates further clinicopathologic definition of this type of lymphoma. Most CD56+ lymphomas display angiocentric histologic features, especially in Asian patients, and these are mostly associated with the presence of Epstein-Barr virus (EBV) genome and with an aggressive clinical course. We report on a young woman with a primary cutaneous blastic NK lymphoma which showed no angiocentric features but showed an unusual immunophenotype; CD56+, TdT+, CD4+, EBV-, and germline configuration of T-cell receptor gene. This unusual lymphoblastic lymphoma seems to have an immature or progenitor NK cell lineage. |
| Databáze: | OpenAIRE |
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