CSF neurofilament light may predict progression from amnestic mild cognitive impairment to Alzheimer's disease dementia
| Autor: | Pradeepthi Bathala, Bryant Lim, Shraddha S. Kale, Ioannis Prassas, Martin Stengelin, Eleftherios P. Diamandis, Christopher Campbell, Sigrid Botne Sando, Gøril Rolfseng Grøntvedt, Geir Bråthen |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Male Aging medicine.medical_specialty Time Factors Neurofilament light Disease behavioral disciplines and activities Cerebrospinal fluid Alzheimer Disease Neurofilament Proteins Predictive Value of Tests Internal medicine mental disorders medicine Dementia Humans Cognitive Dysfunction Longitudinal Studies Cognitive impairment Aged business.industry General Neuroscience Neurodegeneration Middle Aged medicine.disease Cohort Disease Progression Biomarker (medicine) Female Neurology (clinical) Geriatrics and Gerontology business Biomarkers Developmental Biology |
| Zdroj: | Neurobiology of Aging |
| ISSN: | 1558-1497 |
| Popis: | Neurofilament light (NfL) is a promising biomarker of neurodegeneration in Alzheimer's disease (AD). In this study, cerebrospinal fluid (CSF) NfL was measured in a 24-month longitudinal cohort consisting of control (n = 52), amnestic mild cognitive impairment (aMCI) (n = 55), and probable AD dementia (n = 28) individuals. The cohort was reevaluated after 6-10 years. Baseline CSF NfL was significantly elevated in aMCI and probable AD dementia groups compared to controls (p < 0.0001). CSF NfL was significantly lower in stable aMCI patients compared to aMCI patients who converted to probable AD dementia within the 24-month period (p = 0.004). Substituting T-tau for NfL in the core AD biomarkers model (Aβ42/P-tau/T-tau) did not improve ability to separate control and AD, or stable and converter aMCI patients. Our results support that elevated CSF NfL could predict progression in aMCI patients, but its utility cannot improve the core AD biomarkers. This is an open access article distributed under the terms of the Creative Commons CC-BY license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Databáze: | OpenAIRE |
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