Radiotherapy of exudative age-related macular degeneration; a clinical and pathologic study
| Autor: | Mike Kliffen, Cornelia M. Mooy, Robert W A M Kuijpers, Antoinette C Lambooij |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Pathology medicine.medical_specialty genetic structures medicine.medical_treatment Eye disease Antigens Differentiation Myelomonocytic Antigens CD34 Immunoenzyme Techniques Macular Degeneration Cellular and Molecular Neuroscience Antigens CD medicine Humans Radiometry Aged Choroid CD68 business.industry Macrophages Retinal Vessels Exudates and Transudates Macular degeneration medicine.disease Choroidal Neovascularization eye diseases Sensory Systems Radiation therapy Ophthalmology medicine.anatomical_structure Choroidal neovascularization Maculopathy Endothelium Vascular sense organs medicine.symptom business Retinopathy |
| Zdroj: | Graefe's Archive for Clinical and Experimental Ophthalmology. 239:539-543 |
| ISSN: | 1435-702X 0721-832X |
| Popis: | Background: Radiotherapy has recently been employed to treat patients with exudative macular degeneration in order to prevent severe visual loss. Radiotherapy affects the evolution of exudative macular degeneration directly by endothelial toxicity, leading to capillary closure, and/or indirectly through its attenuating effects on the inflammatory response, mediated by macrophages and other inflammatory cells. Methods: In this study we describe the histopathologic findings in a patient with exudative age-related macular degeneration (AMD) in both eyes whose right eye was treated with radiotherapy (5 times 2 Gy) 3 years before he died. The eyes were enucleated post mortem and investigated by light microscopy. Additionally, immunohistochemical investigation with antibodies against CD34 and CD68 was performed to identify patent endothelial cells and macrophages. Results: Both eyes showed neovascular AMD consisting of mixed fibrocellular and fibrovascular membranes. Capillaries in both the choriocapillaris and the neovascular membrane were patent in both eyes. Macrophages were present in the choroidal neovascularization of both eyes. Neither preexistent choroidal, intraretinal, nor neovascular vessels showed increased wall thickness as sign of radiation damage. Conclusion: No radiation-related histopathologic effect could be demonstrated 3 years after radiation therapy in this patient with AMD. |
| Databáze: | OpenAIRE |
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