Decrease of Non‐Classical and Intermediate Monocyte Subsets in Severe Acute SARS‐CoV ‐2 Infection

Autor: Danilo Radrizzani, Bruno Brando, Arianna Gatti, Antonino Mazzone, Paolo Viganò
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
viruses
Cell Separation
Non Classical Monocytes
Severity of Illness Index
Monocytes
0302 clinical medicine
Classical Monocytes
Leukocytes
CD11b Antigen
medicine.diagnostic_test
INT
Middle Aged
respiratory system
Flow Cytometry
Multicolor Flow Cytometry
Phenotype
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
Original Article
Coronavirus Infections
Intermediate Monocytes
SARS‐CoV2
Histology
Pneumonia
Viral
Pathology and Forensic Medicine
Flow cytometry
Betacoronavirus
03 medical and health sciences
COVID‐19
Severity of illness
medicine
Humans
Pandemics
Pathological
Aged
Lung
Host Microbial Interactions
SARS-CoV-2
business.industry
COVID-19
Original Articles
Cell Biology
biochemical phenomena
metabolism
and nutrition
medicine.disease
030104 developmental biology
Immunology
Cytokine storm
business
Cytometry
Biomarkers
Zdroj: Cytometry
Cytometry Part A
ISSN: 1552-4930
1552-4922
DOI: 10.1002/cyto.a.24188
Popis: In patients with severe SARS‐CoV‐2 infection the development of cytokine storm induces extensive lung damage, and monocytes play a role in this pathological process. Non‐classical (NC) and intermediate (INT) monocytes are known to be involved during viral and bacterial infections. In this study 30 patients with different manifestations of acute SARS‐CoV‐2 infection were investigated with a flow cytometric study of NC, INT and classical (CL) monocytes. Significantly reduced NC and INT monocytes and a down‐regulated HLA‐DR were found in acute patients with severe SARS‐CoV‐2 symptoms. Conversely in patients with moderate symptoms NC and INT monocytes and CD11b expression were increased. This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
Externí odkaz: