Prevalence of sacroiliitis and acute and structural changes on MRI in patients with psoriatic arthritis
Autor: | Jailson Rodrigues Lopes, Samily Cordeiro De Oliveira, Carlos Leite De Macedo Filho, Lysiane Maria Adeodato Ramos, Antonio Helder Costa Vasconcelos, Carlos Ewerton Maia Rodrigues, Marcio Vale Braga |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male musculoskeletal diseases medicine.medical_specialty lcsh:Medicine Gastroenterology Article 030207 dermatology & venereal diseases 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Medical research Psoriasis Internal medicine medicine Back pain Humans Sacroiliitis lcsh:Science BASDAI Aged 030203 arthritis & rheumatology Sacroiliac joint Multidisciplinary medicine.diagnostic_test business.industry Arthritis Psoriatic lcsh:R Enthesitis Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Early Diagnosis Female lcsh:Q medicine.symptom business |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) Scientific Reports |
ISSN: | 2045-2322 |
DOI: | 10.1038/s41598-020-68456-7 |
Popis: | Sacroiliac joint involvement is one of the earliest manifestations of psoriatic arthritis (PsA). Magnetic resonance imaging (MRI) is a useful tool in the early diagnosis of axial disease due to its sensitivity for detecting acute and chronic changes associated with sacroiliitis. In this study, we evaluated the prevalence of sacroiliitis, acute and structural image changes on MRI in PsA patients and identified predictive clinical, laboratory and disease activity factors. Cross-sectional study on PsA patients submitted to MRI of the sacroiliac joints. The scans were evaluated by two blinded radiologists and the level of agreement was calculated (kappa). Clinical, disease activity and quality-of-life indices (DAS28, BASDAI, PASI, MASES, HAQ, CRP, ESR) were estimated. The sample consisted of 45 PsA patients with a mean age of 50.1 ± 11.5 years. The prevalence of sacroiliitis was 37.8% (n = 17), 47% of which was unilateral. The kappa coefficient was 0.64. Only 5 (29.4%) of the 17 patients with sacroiliitis on MRI had back pain. The most prevalent acute and chronic changes on MRI were, respectively, subchondral bone edema (26.7%) and enthesitis (20%), periarticular erosions (26.7%) and fat metaplasia (13.3%). CRP levels were higher among sacroiliitis patients (p = 0.028), and time of psoriasis was positively associated with chronic lesions (p = 0.006). Sacroiliitis on MRI was highly prevalent in our sample of PsA patients. Raised CRP levels were significantly associated with sacroiliitis, and longer time of psoriasis was predictive of chronic sacroiliitis lesions. Most sacroiliitis patients displayed no clinical symptoms. |
Databáze: | OpenAIRE |
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