Prooxidant-Antioxidant Balance in the Prostate and Blood of Rats with Sulpyride-Induced Prostatic Hyperplasia Corrected with Prostatilen
| Autor: | O. N. Gomon, L. I. Belostotskaya, V. N. Dzyuba, Yu. V. Nikitchenko, L. A. Chaika, V. V. Bondar |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Lipid Peroxides medicine.medical_specialty Antioxidant medicine.medical_treatment Prostatic Hyperplasia General Biochemistry Genetics and Molecular Biology Lipid peroxidation Increased lipid chemistry.chemical_compound Prostate Internal medicine medicine Animals chemistry.chemical_classification Glutathione Peroxidase Chemistry Glutathione peroxidase Rats Inbred Strains General Medicine Hyperplasia medicine.disease Rats Prostatilen Antioxidant capacity Endocrinology medicine.anatomical_structure Sulpiride Peptides Oxidation-Reduction |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 139:334-336 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-005-0287-1 |
| Popis: | We studied the effects of 30-day injections of sulpyride and treatment with Prostatilen on the development of prostatic hyperplasia and LPO in rats. Sulpyride induced proliferation of lateral lobes, increased the content of lipid hydroperoxides and glutathione peroxidase activity in the gland; in the blood this preparation increased lipid hydroperoxide concentration and decreased glutathione peroxidase and total antioxidant activity. Prostatilen prevented the development of hyperplasia and normalized the prooxidant-antioxidant balance in tissues, except total antioxidant activity of the blood. |
| Databáze: | OpenAIRE |
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