Chronic rhinosinusitis with nasal polyps is characterized by dysbacteriosis of the nasal microbiota
| Autor: | Thibaut Van Zele, Thanit Chalermwatanachai, Ramiro Vilchez-Vargas, Gabriele Holtappels, Dietmar H. Pieper, Claus Bachert, Mario Vaneechoutte, Ruy Jauregui, Tom Van de Wiele, Frederiek-Maarten Kerckhof, Tim Lacoere |
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| Přispěvatelé: | HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany., Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany. |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male PROTEIN lcsh:Medicine medicine.disease_cause Immunoglobulin E DISEASE Haemophilus influenzae COLONIZATION SINUS MICROBIOTA Medicine and Health Sciences Nasal polyps lcsh:Science Rhinitis Multidisciplinary ENTEROTOXINS biology Bacterial Infections Middle Aged 3. Good health Staphylococcus aureus Nasal Swab Female Adult Nose Article 03 medical and health sciences Propionibacterium acnes Nasal Polyps medicine Humans IGE Sinusitis Asthma STAPHYLOCOCCUS-AUREUS Inflammation COMPLEXITY Bacteria business.industry lcsh:R Case-control study Biology and Life Sciences medicine.disease biology.organism_classification 030104 developmental biology TISSUE Case-Control Studies Immunology Chronic Disease biology.protein ASTHMA Dysbiosis lcsh:Q business |
| Zdroj: | Scientific Reports Scientific reports Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018) SCIENTIFIC REPORTS |
| ISSN: | 2045-2322 |
| Popis: | Chronic rhinosinusitis with nasal polyp (CRSwNP) patients are often characterized by asthma comorbidity and a type-2 inflammation of the sinonasal mucosa. The mucosal microbiota has been suggested to be implicated in the persistence of inflammation, but associations have not been well defined. To compare the bacterial communities of healthy subjects with CRSwNP patients, we collected nasal swabs from 17 healthy subjects, 21 CRSwNP patients without asthma (CRSwNP−A), and 20 CRSwNP patients with co-morbid asthma (CRSwNP+A). We analysed the microbiota using high-throughput sequencing of the bacterial 16S rRNA. Bacterial communities were different between the three groups. Haemophilus influenzae was significantly enriched in CRSwNP patients, Propionibacterium acnes in the healthy group; Staphylococcus aureus was abundant in the CRSwNP−A group, even though present in 57% of patients. Escherichia coli was found in high amounts in CRSwNP+A patients. Nasal tissues of CRSwNP+A patients expressed significantly higher concentrations of IgE, SE-IgE, and IL-5 compared to those of CRSwNP−A patients. Co-cultivation demonstrated that P. acnes growth was inhibited by H. influenzae, E. coli and S. aureus. The nasal microbiota of healthy subjects are different from those of CRSwNP−A and CRSwNP+A patients. However, the most abundant species in healthy status could not inhibit those in CRSwNP disease. |
| Databáze: | OpenAIRE |
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