Structural Abnormalities in the Levator Palpebrae Superioris Muscle in Patients With Congenital Blepharoptosis
| Autor: | Andrzej Zielinski, Aleksandra Omulecka, Michal Karasek, Anna Zielińska, Aleksandra Iljin |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Levator palpebrae superioris muscle Immunoenzyme Techniques Myofibrils Blepharoptosis Humans Medicine Child Perimysium business.industry Hyperplasia Levator Palpebrae Superioris Endomysium medicine.disease Mitochondria Muscle Oculomotor Muscle medicine.anatomical_structure Oculomotor Muscles Child Preschool Ultrastructure Female business Myofibril Biomarkers |
| Zdroj: | Ophthalmic Surgery, Lasers and Imaging Retina. 38:283-289 |
| ISSN: | 2325-8179 2325-8160 |
| DOI: | 10.3928/15428877-20070701-03 |
| Popis: | BACKGROUND AND OBJECTIVE To evaluate structural and ultrastructural abnormalities of the levator palpebrae superioris (LPS) complex in patients with congenital blepharoptosis. PATIENTS AND METHODS Samples of the LPS complex were obtained from patients operated on for congenital blepharoptosis between 2000 and 2001 and studied under light microscopy (15 cases) and electron microscopy (9 cases). RESULTS Findings of light microscopy evaluation of the LPS complex correlated closely with the clinical grading of congenital blepharoptosis-hypoplasia, decreased number and varying diameter of muscle fibers, and fibrous tissue hyperplasia in the endomysium and perimysium. The Müller’s muscle preserved a normal appearance. Mild blepharoptosis revealed proliferation of collagen fibers on electron microscopy. Moderate blepharoptosis showed abnormal distribution of myofibrils and distortion of the tubular system and mitochondria in addition to the changes observed in mild blepharoptosis. Severe blepharoptosis showed mitochondria loss, cytoplasm thinning, and homogenous fiber areas in addition to the changes observed in mild and moderate blepharoptosis. CONCLUSIONS The clinical degree of severity of congenital blepharoptosis correlates positively with the degree of histopathologic changes in the levator palpebrae superioris muscle. [Ophthalmic Surg Lasers Imaging 2007;38:283-289.] AUTHORS From the Department of Plastic Surgery (AI, A. Zielinski); the Department of Neuroendocrinology (A. Zielinska, MK); and the Department of Pathomorphology (AO); Medical University of Lódz, Lódz, Poland. Accepted for publication December 10, 2006. Presented at the 9th Congress of the Polish Society of Plastic, Reconstructive and Aesthetic Surgery, in Warsaw, Poland, November 6-8, 2003. Part of the PhD dissertation of Aleksandra Iljin. Supported by grants 502-11-551(71)-1999 and 6 PO5C 029 21-2001 from the Ministry of Scientific Research and Information Technology, KBN (the State Committee for Scientific Research), Warsaw, Poland. Address correspondence to Aleksandra Iljin, MD, Department of Plastic Surgery, Medical University, ul. Kopcinskiego 22, 90-153 Lódz, Poland. |
| Databáze: | OpenAIRE |
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